When placed non-invasively against skin tissue cycloidal vibration generates a range of mechanical stresses compressive, tensile, shear and distention at cellular level causing a cellular and physiological response. Mechanical stimulation of vascular wall endothelial cells results in production of nitric oxide (eNOS) resulting in vasodilation. This initiates microcirculatory improvement. Vasodilation also increases cellular shear stress against the vascular wall resulting in angiogenic activity and the cellular expression of proteins and growth factors stimulating blood vessel and tissue regeneration.